Orakle Expert's Corner

New activities

Webinar: Reflections and learnings from the early gene therapies for Hemophilia B

Supported byCSL Behring

Classical Hematology • Surgery

Webinar: Reflections and learnings from the early gene therapies for Hemophilia B

webinar

Classical Hematology • Surgery

Webinar: Reflections and learnings from the early gene therapies for Hemophilia B. 2025.

webinar

A late preterm male infant, born at 37 weeks via cesarean delivery, presents with respiratory distress and skeletal abnormalities.

Supported byAlexion, AstraZeneca Rare Disease

Mario, a 4-year-old male, presents with diffuse musculoskeletal pain, difficulty keeping up with peers in physical activities, and delayed motor milestones.

Supported byAlexion, AstraZeneca Rare Disease

Daniel, a 56-year-old man, presents with a history of recurrent non-traumatic fractures, chronic fatigue, and foot pain, which have progressively worsened over the last 6 months

Supported byAlexion, AstraZeneca Rare Disease

Recommended For You

Webinar: Reflections and learnings from the early gene therapies for Hemophilia B

Supported byCSL Behring

1hr 20m

Classical Hematology • Surgery

Progressive respiratory distress in a 53-year-old female

Supported byOrakle LLC

15m

Oncology • Radiology • Pulmonology

A 56-year-old patient develops a fever during hospitalization.

Supported byPfizer

15m

Infectious Diseases • Pulmonology • Critical Care Medicine

A 64-year-old woman on long-term immunosuppressive therapy presents to the emergency department with fever and chills.

Supported byPfizer

15m

Infectious Diseases • Gastroenterology • Critical Care Medicine

A 14-year-old girl presents with joint pain, fatigue, muscle weakness, and social withdrawal.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

A 59-year-old woman with end-stage renal disease secondary to atypical hemolytic uremic syndrome has identified a kidney donor and presents today to evaluate her risk of aHUS relapse following transplantation.

Supported byAlexion, AstraZeneca Rare Disease

15m

Nephrology • Clinical Immunology • Obstetrics and Gynecology

A 67-year-old man with metastatic castration-resistant prostate cancer presents with symptoms and a prostate-specific antigen rise concerning for disease progression.

Supported byNovartis

15m

Urology • Oncology • Radiology

A 34-year-old with treatment-resistant psychosis and progressive gait instability.

Supported byZevra Therapeutics

15m

Neurology • Endocrinology • Psychiatry

Relapsing neurological symptoms in a 51-year-old female.

Supported byUCB

15m

Ophthalmology • Neurology • Emergency Medicine

Chloe presents with decreased urine output, vomiting, malaise, and shortness of breath.

Supported byAlexion, AstraZeneca Rare Disease

15m

Emergency Medicine • Critical Care Medicine • Nephrology

Popular Activities

Webinar: Reflections and learnings from the early gene therapies for Hemophilia B

Supported byCSL Behring

webinar

Classical Hematology • Surgery

A 74-year-old woman with chronic heart failure and persistent fatigue.

Supported byOrakle LLC

15m

Classical Hematology • Cardiology • Geriatric Medicine

A 47-year-old patient with uncontrolled type 2 diabetes mellitus on 2 oral agents.

Supported byOrakle LLC

15m

Endocrinology • Obstetrics and Gynecology • Nephrology

A 28-year-old male presenting with gross haematuria and foamy urine.

Supported byOrakle LLC

15m

Nephrology • Medical Genetics • General Practice/Family Medicine

A 28-year-old woman with psoriasis and psoriatic arthritis.

Supported byOrakle LLC

15m

Dermatology • Rheumatology • Obstetrics and Gynecology

A 48-year-old man with chronic pancreatitis and severe malabsorption is experiencing progressive weight loss.

Supported byOrakle LLC

15m

Clinical Nutrition • Gastroenterology • Pancreatology

A woman presents with worsening shortness of breath on exertion.

Supported byOrakle LLC

15m

Cardiology • Pulmonology • Medical Genetics

Painless bilateral vision loss in a patient with a history of age-related macular degeneration.

Supported byOrakle LLC

15m

Ophthalmology • Rheumatology • Geriatric Medicine

A 71-year-old woman presents to the ophthalmology department with visual deterioration following cataract surgery.

Supported byOrakle LLC

15m

Ophthalmology • Endocrinology

A 7-year-old girl with scattered hyperpigmented skin lesions and a deep-seated mass.

Supported byOrakle LLC

15m

Dermatology • Oncology • Surgery

A 35-year-old woman with severe obesity, type 2 diabetes, polycystic ovary syndrome, fatty liver disease, knee osteoarthritis, and bipolar disorder complicated by antipsychotic-associated weight gain, presenting for weight management.

Supported byOrakle LLC

15m

Psychiatry • Gastroenterology • Endocrinology

A routine employment checkup detected abnormal urinalysis.

Supported byOrakle LLC

15m

Nephrology • Clinical Immunology • Allergy and Immunology

A 76-year-old woman with NSCLC and disease progression.

Supported byOrakle LLC

15m

Pulmonology • Clinical Pathology • Oncology

An elderly man presenting with a 2-month history of progressive fatigue during routine daily activities.

Supported byOrakle LLC

15m

Cardiology • Nephrology • Classical Hematology

Persistent right shoulder pain and limited progress in rehabilitation three months after open reduction and internal fixation for a proximal humeral fracture, despite prior analgesic treatment and corticosteroids.

Supported byOrakle LLC

15m

Rheumatology • Pain Medicine • Obstetrics and Gynecology

A woman presents to the emergency department one month ago, after sustaining a fall at home.

Supported byOrakle LLC

15m

Neurology • Endocrinology • Obstetrics and Gynecology

A Woman seeking oral contraception and cycle regulation with a history of VTE and prior intolerance to a progestin-only pill.

Supported byOrakle LLC

15m

General Practice/Family Medicine • Obstetrics and Gynecology

A dialysis-dependent man in his 70s with recurrent Sweet syndrome-like flares over 2 years, responsive to corticosteroids but relapsing with taper.

Supported byOrakle LLC

15m

Nephrology • Allergy and Immunology • Clinical Immunology

A 55-year-old man with CI-DME and fluctuating response to anti-VEGF monotherapy.

Supported byOrakle LLC

15m

Ophthalmology • Endocrinology

Persistent hyperglycemia despite insulin therapy.

Supported byOrakle LLC

15m

Endocrinology • Emergency Medicine • Obstetrics and Gynecology

A 44-year-old woman with relapsed diffuse large B-cell lymphoma is to begin stem cell mobilization before planned autologous stem cell transplantation.

Supported byOrakle LLC

15m

Oncology • Hematology (Malignant) • Clinical Pathology

A 69-year-old male with haematuria.

Supported byOrakle LLC

15m

Radiology • Urology • Oncology

A 56-year-old woman with end-stage renal disease presents to the emergency department with 2 days of fever and a painful rash affecting both hands.

Supported byOrakle LLC

15m

Emergency Medicine • Intensive Care Medicine • Nephrology

Type 1 diabetes mellitus misdiagnosed as type 2 diabetes mellitus, resulting in inadequate treatment and poor disease management

Supported byOrakle LLC

15m

Endocrinology • General Practice/Family Medicine

Renal cell carcinoma (mRCC), initially treated with nephrectomy, now presents with a persistent cough.

Supported byOrakle LLC

15m

Oncology • Surgery • Radiology

Abdominal pain, nausea, decreased appetite, and abdominal distension in a 45-year-old woman

Supported byOrakle LLC

15m

Hepatology • Gastroenterology • Infectious Diseases

A 12-year-old boy with tooth pain, fatigue, and muscle weakness.

Supported byOrakle LLC

15m

Pediatrics • Rheumatology • Neurology

A young boy presents with short stature and delayed bone age.

Supported byOrakle LLC

15m

Pediatrics • Medical Genetics • General Practice/Family Medicine

A patient with Crohn’s disease presents with an asymptomatic recurrence.

Supported byOrakle LLC

15m

Surgery • Gastroenterology • Clinical Immunology

A 35-year-old man with fatigue, muscle weakness and breathing discomfort.

Supported byOrakle LLC

15m

Neurology • Medical Genetics • Pulmonology

Persistent symptoms in a 68-year-old man with polycythemia vera (PV) despite ongoing phlebotomy and escalating hydroxyurea therapy.

Supported byOrakle LLC

15m

Hematology (Malignant) • Oncology • Radiology

A 68-year-old woman with locally advanced cutaneous squamous cell carcinoma.

Supported byOrakle LLC

15m

Dermatology • Radiology • Oncology

A 63-year-old woman with newly diagnosed DLBCL.

Supported byOrakle LLC

15m

Hematology (Malignant) • Oncology

A man with ocular redness in both eyes 1 week before a sudden bilateral decrease in visual acuity.

Supported byOrakle LLC

15m

Ophthalmology • Radiology • Oncology

A 45-year-old African American woman with ESRD is eager to understand her risk of organ rejection after the transplant.

Supported byThermo Fisher Scientific

15m

Transplantation Medicine • Nephrology • Surgery

A 71-year-old woman with progressive lymphadenopathy.

Supported byOrakle LLC

15m

Hematology (Malignant) • Oncology • Clinical Pathology

A 65-year-old woman with a history of invasive ductal carcinoma of the left breast presented with a left supraclavicular recurrence after 10 years.

Supported byOrakle LLC

15m

Oncology • Surgery • Radiology

A 69-year-old male with a history of PSMA-positive mCRPC presents with persistent fatigue and shortness of breath on exertion.

Supported byNovartis

15m

Oncology • Urology • Nuclear Medicine

A patient with non-small cell lung cancer (NSCLC) returns with new-onset fatigue and dark-colored urine.

Supported byOrakle LLC

15m

Oncology • Hepatology • Pulmonology

A 68-year-old male with a history of metastatic hormone-sensitive prostate cancer (mHSPC) presents with symptoms concerning for disease progression.

Supported byNovartis

15m

Urology • Oncology • Radiology

A 72-year-old man with metastatic castration-resistant prostate cancer presenting with a rising prostate-specific antigen, without accompanying clinical symptoms.

Supported byNovartis

15m

Urology • Oncology • Radiology

A 67-year-old man with metastatic castration-resistant prostate cancer presents with symptoms and a prostate-specific antigen rise concerning for disease progression.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇨🇳 一名 67 岁男性，确诊转移性去势抵抗性前列腺癌（mCRPC），现出现症状并伴有前列腺特异性抗原（PSA）升高，提示疾病进展。

Supported by诺华制药公司

15m

Urology • Oncology • Radiology

Relapsing neurological symptoms in a 51-year-old female.

Supported byUCB

15m

Ophthalmology • Neurology • Emergency Medicine

🇨🇳 患者 69 岁男性，既往患有 PSMA 阳性去势抵抗性前列腺癌（mCRPC），现因持续性疲劳及活动后呼吸困难就诊。

Supported by诺华制药公司

15m

Urology • Oncology • Radiology

George underwent a kidney transplant one month ago. He presents today with concerns about decreased urine output over the past several days.

Supported byThermo Fisher Scientific

15m

Transplantation Medicine • Nephrology • Surgery

🇨🇳 患者，男，68岁，既往有转移性激素敏感性前列腺癌（mHSPC）病史，现因出现提示疾病进展的症状就诊。

Supported by诺华制药公司

15m

Urology • Oncology • Radiology

🇨🇳 一名 72 岁男性，确诊转移性去势抵抗性前列腺癌（mCRPC），现出现症状并伴有前列腺特异性抗原（PSA）升高，提示疾病进展

Supported by诺华制药公司

15m

Urology • Oncology • Radiology

43-year-old man with a 20-year history of HIV-1 and persistent viremia despite multiple prior regimens.

Supported byOrakle LLC

15m

General Practice/Family Medicine • Infectious Diseases • Sexual Health/Venerology

Blurry vision after cataract surgery.

Supported byOrakle LLC

15m

Ophthalmology

A 60-year-old woman with a history of simultaneous pancreas-kidney transplant and subsequent living-donor kidney transplant presents with new-onset BK viremia.

Supported byVerici Dx

15m

Surgery • Nephrology • Clinical Pathology

A 42-year-old transplant recipient with rising CXCL10 levels but normal conventional biomarkers.

Supported byThermo Fisher Scientific

15m

Nephrology • Transplantation Medicine • Clinical Pathology

A 4-year-old presents with diffuse musculoskeletal pain and difficulty keeping up with peers.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Gastroenterology • Pediatrics

A man with ESRD due to diabetes and hypertension experiences delayed graft function after a kidney transplant.

Supported byVerici Dx

15m

Surgery • Nephrology • Clinical Pathology

A 14-year-old girl presents with joint pain, fatigue, muscle weakness, and social withdrawal.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Chloe presents with decreased urine output, vomiting, malaise, and shortness of breath.

Supported byAlexion, AstraZeneca Rare Disease

15m

Emergency Medicine • Critical Care Medicine • Nephrology

Supported byAlexion, AstraZeneca Rare Disease

15m

Nephrology • Clinical Immunology • Obstetrics and Gynecology

Laura presents with a persistent headache, blurred vision, nausea, vomiting, general malaise, and blood pressure recorded at 230/140 mmHg.

Supported byAlexion, AstraZeneca Rare Disease

15m

Cardiology • Obstetrics and Gynecology • Emergency Medicine

A 56-year-old presents with recurrent non-traumatic fractures, chronic fatigue, and foot pain.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Endocrinology • Radiology

A late preterm presents with respiratory distress and skeletal abnormalities.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Amanda presents with recurrent headaches, hypertension, and worsening renal function four months after breast implantation.

Supported byAlexion, AstraZeneca Rare Disease

15m

Cardiology • Obstetrics and Gynecology • Nephrology

A 62-year-old woman, presents with chronic pain, fatigue, and worsening depression.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Endocrinology • Radiology

A 32-year-old woman, gestational age: 35 weeks, scheduled for a cesarean section presents with signs of preeclampsia without severe features, and her husband is diagnosed with active varicella.

Supported byKamada, Inc / PRO-VAR-1202-v1.

15m

Obstetrics and Gynecology • Clinical Immunology • Infectious Diseases

Joe, a 14-year-old boy who underwent a kidney transplant 5 months ago, was exposed to VZV through a friend.

Supported byKamada, Inc / PRO-VAR-1210-v1.

15m

Pediatrics • Transplantation Medicine • Infectious Diseases

A young girl presents with developmental regression.

Supported byZevra Therapeutics

15m

Neurology • Pediatrics • Endocrinology

A 34-year-old with treatment-resistant psychosis and progressive gait instability.

Supported byZevra Therapeutics

15m

Neurology • Endocrinology • Psychiatry

Sarah is an 8-year-old girl with a history of sJIA. Four days ago, Sarah returned from a class trip to Japan, and today she was informed that a classmate on the trip was diagnosed with varicella (chickenpox).

Supported byKamada, Inc / PRO-VAR-1211-v1.

15m

Rheumatology • Pediatrics • Clinical Immunology

A 29-year-old pregnant woman presents with concerns following confirmed varicella exposure in the waiting room at your office.

Supported byKamada, Inc / PRO-VAR-1205-v1.

15m

Obstetrics and Gynecology • Clinical Immunology • Infectious Diseases

Gary is a 28-week preterm infant currently in the NICU. He was exposed to varicella (chickenpox) through his 3-year-old sibling, who visited him in the NICU.

Supported byKamada, Inc / PRO-VAR-1209-v1.

15m

Neonatology • Pediatrics • Intensive Care Medicine

Emma, a 6-year-old girl with a history of AML, visited her grandmother three days ago, and today her parents were informed that the grandmother has been diagnosed with varicella-zoster virus.

Supported byKamada, Inc / PRO-VAR-1208-v1

15m

Transplantation Medicine • Oncology • Pediatrics

68-year-old man on daily oral HIV PrEP, where repeated HIV antigen/antibody tests are reactive, but confirmatory viral load testing remained undetectable.

Supported byOrakle LLC

15m

Infectious Diseases • Sexual Health/Venerology • General Practice/Family Medicine

A Young Woman Presenting With Headaches and Peripheral Vision Changes.

Supported byOrakle LLC

15m

Neurology • Ophthalmology • Obstetrics and Gynecology

Severe perioperative bleeding in cardiac surgery.

Supported byOrakle LLC

15m

Anesthesiology • Surgery • Classical Hematology

🇫🇷 Homme de 69 ans, ayant des antécédents de mCRPC PSMA-positif, consultant pour une fatigue persistante et une dyspnée d’effort.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇩🇪 Ein 72-jähriger Mann mit metastasiertem kastrationsresistentem Prostatakreb mit einem steigenden Prostata-spezifischen Antigen ohne begleitende klinische Symptome.

Supported byNovartis

15m

Urology • Oncology • Radiology

A patient with non-small cell lung cancer (NSCLC) returns with new-onset fatigue and dark-colored urine.

Supported byOrakle LLC

15m

Oncology • Hepatology • Surgery

🇫🇷 Homme de 72 ans atteint d’un cancer de la prostate métastatique résistant à la castration présentant une hausse de l’antigène spécifique de la prostate, sans symptômes cliniques associés.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇩🇪 Ein 68-jähriger Mann mit einer Vorgeschichte von metastasiertem hormonsensitivem Prostatakrebs zeigt Symptome, die auf ein Fortschreiten der Erkrankung hindeuten.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇩🇪 Ein 67-jähriger Mann mit metastasiertem kastrationsresistentem Prostatakrebs zeigt Symptome und einen Anstieg des prostataspezifischen Antigens, die auf ein Fortschreiten der Erkrankung hindeuten.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇩🇪 Ein 69-jähriger Mann mit einer Vorgeschichte von PSMA-positivem metastasiertem kastrationsresistentem Prostatakarzinom stellt sich mit persistierender Fatigue und Belastungsdyspnoe vor.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇫🇷 Homme âgé de 68 ans ayant des antécédents de cancer de la prostate métastatique hormonosensible présente des symptômes évoquant une progression de la maladie

Supported byNovartis

15m

Urology • Oncology • Radiology

🇫🇷 Homme de 67 ans atteint d’un cancer de la prostate métastatique résistant à la castration présentant des symptômes et une élévation de l’antigène spécifique de la prostate suggérant une progression de la maladie.

Supported byNovartis

15m

Urology • Oncology • Radiology

🇯🇵 転移性去勢抵抗性前立腺がん（mCRPC）を有する72歳男性。臨床症状は認められず、前立腺特異抗原（PSA）の上昇を呈している。

Supported byノバルティス

15m

Urology • Oncology • Radiology

🇯🇵 PSMA陽性mCRPCの既往を有する69歳男性が、持続する倦怠感と労作時の呼吸困難を主訴に受診した。

Supported byノバルティス

15m

Urology • Oncology • Radiology

🇯🇵 67歳の男性で、転移性去勢抵抗性前立腺がん（mCRPC）を有しており、疾患進行が疑われる症状と前立腺特異抗原（PSA）の上昇を呈している。

Supported byノバルティス

15m

Urology • Oncology • Radiology

🇯🇵 転移性ホルモン感受性前立腺がん（mHSPC）の既往を有する68歳男性が、病勢進行が懸念される症状を呈している。

Supported byノバルティス

15m

Urology • Oncology • Radiology

A 64-year-old woman on long-term immunosuppressive therapy presents to the emergency department with fever and chills.

Supported byPfizer

15m

Infectious Diseases • Gastroenterology • Critical Care Medicine

A 56-year-old patient develops a fever during hospitalization.

Supported byPfizer

15m

Infectious Diseases • Pulmonology • Critical Care Medicine

A 62-year-old woman presents with fever and diffuse abdominal pain after sigmoid colectomy for diverticulitis.

Supported byPfizer

15m

Infectious Diseases • Emergency Medicine • Critical Care Medicine

A 68-year-old man presents with dysuria, urgency, and frequency.

Supported byPfizer

15m

Infectious Diseases • Urology • Clinical Pathology

A late preterm male infant, born at 37 weeks via cesarean delivery, presents with respiratory distress and skeletal abnormalities.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Mario, a 4-year-old male, presents with diffuse musculoskeletal pain, difficulty keeping up with peers in physical activities, and delayed motor milestones.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Gastroenterology • Pediatrics

Daniel, a 56-year-old man, presents with a history of recurrent non-traumatic fractures, chronic fatigue, and foot pain, which have progressively worsened over the last 6 months

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Mariam, a 14-year-old girl, presents with joint pain, fatigue, muscle weakness, diminished hearing, and social withdrawal.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Antonia, a 62-year-old woman, presents with chronic pain, fatigue, and worsening depression. Her symptoms date back to childhood.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

A late preterm male infant, born at 37 weeks via cesarean delivery, presents with respiratory distress and skeletal abnormalities.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Mariam, a 14-year-old girl, presents with joint pain, fatigue, muscle weakness, diminished hearing, and social withdrawal.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Mario, a 4-year-old male, presents with diffuse musculoskeletal pain, difficulty keeping up with peers in physical activities, and delayed motor milestones.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Gastroenterology • Pediatrics

Daniel, a 56-year-old man, presents with a history of recurrent non-traumatic fractures, chronic fatigue, and foot pain, which have progressively worsened over the last 6 months

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Antonia, a 62-year-old woman, presents with chronic pain, fatigue, and worsening depression. Her symptoms date back to childhood.

Supported byAlexion, AstraZeneca Rare Disease

15m

Hepatology • Pediatrics • Endocrinology

Progressive respiratory distress in a 53-year-old female

Supported byOrakle LLC

15m

Oncology • Radiology • Pulmonology